The process of LTP is regarded as a contributing factor to synaptic plasticity and in the growth of synaptic strength, which are suggested to underlie memory formation.
LTP is also considered to be an important mechanism in terms of maintaining memories within brain regions, There is compelling evidence that LTP is critical for Pavlovian fear conditioning in rats suggesting that it mediates learning and memory in mammals.
These studies were accompanied by the creation of animal models of human amnesia in an effort to identify brain substrates critical for slow consolidation.
Meanwhile, neuropharmacological studies of selected brain areas began to shed light on the molecules possibly responsible for fast consolidation.
Studies have shown that protein synthesis inhibitors administered after learning, weaken memory, suggesting that protein synthesis is required for memory consolidation.
Additionally, reports have suggested that the effects of protein synthesis inhibitors also inhibit LTP.
An exception to this 24-hour rule is long-term potentiation, or LTP, a model of synaptic plasticity related to learning, in which an hour is thought to be sufficient.In recent decades, advancements in cellular preparations, molecular biology, and neurogenetics have revolutionized the study of consolidation.