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Defects in this process can lead to severe ataxia (1), mental retardation, and seizures (2).
These findings show that the increase in granule cell number is not due to a region-specific sampling or mouse strain effect. Although other proteases in brain such as the kallikreins (16) can activate plasminogen, they are less effective activators.
Using a dissection microscope, the Di I crystals were removed and the coverslip was placed in a Dvorak–Stotler chamber and viewed with a Bio-Rad 600 confocal microscope with the lowest laser setting and attenuated 90% with neutral density filters to reduce cell damage.